rabbit anti drd1 (Danaher Inc)
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86
Structured Review
Danaher Inc
rabbit anti drd1
Rabbit Anti Drd1, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti drd1/product/Danaher Inc
Average 86 stars, based on 1 article reviews
Rabbit Anti Drd1, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti drd1/product/Danaher Inc
Average 86 stars, based on 1 article reviews
rabbit anti drd1 - by Bioz Stars,
2026-02
86/100 stars
Images
1) Product Images from "Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging"
Article Title: Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging
Journal: Journal of Alzheimer's disease : JAD
doi: 10.3233/JAD-231002
Figure Legend Snippet: Deregulated hippocampal GHSR and synaptic function in 24-month-old hAβ KI mice. A, B) Hippocampal GHSR level in (A) 14- and (B) 24-month-old hAβ KI mice and the nonTg controls. Unpaired two-way Student’s t test. 14-month-old n = 3 males, 2 females; 24-month-old n = 2 males, 2 females. Bottom panels are the representative images, scale bar = 200 μm (inset scale = 30 μm). C, D) Hippocampal GHSR/β-arrestin 2 complex level in (C) 14- and (D) 24-month-old hAβ KI mice and the nonTg controls. Unpaired two-way Student’s t test. 14-month-old n = 2 males, 2 females; 24-month-old nonTg n = 3 males, 2 females, hAβ KI n = 2 males, 2 females. Bottom panels are the representative images, scale bar = 250 μm (inset scale = 50 μm). E, F) Hippocampal GHSR/DRD1 complex level in (E) 14- and (F) 24-month-old hAβ KI mice and the nonTg controls. Unpaired two-way Student’s t test. 14-month-old n = 2 males, 2 females; 24-month-old n = 2 males, 2 females. Bottom panels are the representative images, scale bar = 250 μm (inset scale = 50 μm). G, H) Hippocampal CamKII activation in (G) 14- and (H) 24-month-old hAβ KI mice and the nonTg controls represented by CamKII Thr286 phosphorylation. Unpaired two-way Student’s t test. 14-month-old nonTg n = 2 males, 2 females, hAβ KI n = 3 males, 2 females; 24-month-old nonTg n = 2 males, 2 females, hAβ KI n = 3 males, 2 females. Bottom panels are the representative images, scale bar = 30 μm. I, J) Hippocampal synaptic density in (I) 14- and (J) 24-month-old hAβ KI mice and the nonTg controls represented by the overlap of presynapse marker vGlut1 and postsynapse marker PSD95. Unpaired two-way Student’s t test. 14-month-old nonTg n = 2 males, 2 females, hAβ KI n = 2 males, 2 females; 24-month-old nonTg n = 2 males, 2 females; hAβ KI n = 2 males, 1 female. Bottom panels are the representative images, scale bar = 100 μm (inset scale = 10 μm). NS = not significant, *p < 0.05. Females: filled circles, males: open circles.
Techniques Used: Activation Assay, Marker
![A Autoradiography. Representative images of autoradiography of D 1 -TG and WT mouse heart sections labeled with 5 nM [ 3 H]SCH23390 (total binding, TB) or 5 nM [ 3 H]SCH23390 + 10 M butaclamol (unspecific binding, UB). B In situ hybridization. Expression of D 1 -dopamine receptor mRNA detected by DIG-labelled human D 1 -dopamine receptor antisense probes (A-X) and DIG-labelled mouse D 1 -dopamine receptor antisense probes (a-l). DIG-labeled sense probes were used as controls. (A-H): Low magnification microscopic images, scale bar = 500 µm. mRNA expression of D 1 -dopamine receptor was not detected in WT mouse atria (A) and ventricles (C); whereas expression of human D 1 -dopamine receptor mRNA was detected in D 1 -Tg mouse atria (E) and ventricles including interventricular septum (G). (B, D, F, H) are corresponding control sections hybridized with DIG-labeled sense probes. (I-X): High magnification microscopic images, scale bar = 50 µm. No or very scarce and weak D 1 -dopamine mRNA expression was detected in WT mouse atria (I) and interventricular septum (K), while abundant human D 1 -dopamine mRNA expression was detected in atriums (M), interventricular septum (O), and ventricle walls (Q, S). (J, L, N, P, R, T) are corresponding control sections hybridized with DIG-labeled sense probes. D 1 -dopamine mRNA expression was also detected in human cardiomyocytes (U, W); while no signal was seen in corresponding control sections hybridized with DIG-labeled sense probes (V, X). (a-d): Low magnification microscopic images, scale bar = 500 µm. (e-h): High magnification microscopic images, scale bar = 50 µm. Expression of mouse D 1 -dopamine receptor mRNA was not detected in WT mouse atria (a, e) and ventricles (c, g); (b, d, f, h) are corresponding control sections hybridized with DIG-labeled sense probes. Low magnification images (i and j, scale bar = 500 µm) and high magnification images (k and l, scale bar = 50 µm) showed that the mouse antisense probe also detected human D 1 -dopamine mRNA expression in D 1 -TG mouse interventricular septum (i, k), while the mouse sense probe (control) did not detect any specific signal (j, l). C : Histology. Histological staining of myocardial sections with hematoxylin-eosin (HE) or Masson-Goldner trichome (MG) staining revealed no apparent abnormalities or signs of fibrosis, neither in WT nor in D 1 -TG. Scale bar = 100 µm. D : PCR. Scatter plots with means for the expression of exogenous transgenic D 1 -dopamine receptors (human-DRD1, left hand side) or endogenous mouse D 1 -dopamine receptors. Ordinates indicate the amount of the mRNA as inferred from the amplification cycles (Cq). *indicates significant differences between the mRNA from the whole heart of D 1 -TG versus WT](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_6794/pmc11166794/pmc11166794__210_2023_2901_Fig2a_HTML.jpg)
